Guest operations manager / file Manager returns a "no route to host" error when attempting to copy from RHEL guest to the vCO appliance

While trying to use the guest script manager package I discovered that for RHEL6 guests we have an issue copying the file back from the guest to vCO. Consistently they all fail in the "Copy file from guest to vCO" workflow, and in testing the error is reproducible.

Specifically, the final step in that workflow - result = fileManager.downloadFile(vcoPath, ftInfo) - generates the error "No route to host (Workflow:Copy file from guest to vCO / Scriptable task (item1)#10)"

Anyone know what might be causing this?